Bitter Blocker for Artificial Sweeteners
May 31, 2010 - News
Comments

CINCINNATI—Scientists have developed a novel bitter receptor antagonist—GIV3727—that effectively can reduce the bitter taste quality of artificial sweeteners in foods, beverages and pharmaceuticals.

Human bitter taste is mediated by the hTAS2R family of G protein-coupled receptors. The discovery of the hTAS2Rs enables the potential to develop specific bitter receptor antagonists that could be beneficial as chemical probes to examine the role of bitter receptor function in gustatory and nongustatory tissues. In addition, they could have widespread utility in food and beverages fortified with vitamins, antioxidants, and other nutraceuticals, because many of these have unwanted bitter aftertastes. The researchers employed a high-throughput screening approach to discover a novel bitter receptor antagonist (GIV3727) that inhibits activation of hTAS2R31 (formerly hTAS2R44) by saccharin and acesulfame K. Pharmacological analyses revealed that GIV3727 likely acts as an orthosteric, insurmountable antagonist of hTAS2R31. They also found that this compound could inhibit five additional hTAS2Rs, including the closely related receptor hTAS2R43. Molecular modeling and site-directed mutagenesis studies suggest that two residues in helix 7 are important for antagonist activity in hTAS2R31 and hTAS2R43. In human sensory trials, GIV3727 significantly reduced the bitterness associated with the two sulfonamide sweeteners, indicating that hTAS2R antagonists are active in vivo.

Sources:

Comments
comments powered by Disqus
Related News
News
The Italian study, even if validated by peers, doesn't necessarily mean the substance poses a
News
A new study published in the International Journal of Public Health suggests children who spend a
News
Innova Market Insights will present on the latest soft drink trends and emerging flavors at its
News
When it comes to children's nutrition, it’s no longer enough for companies to just serve up food