Obesity Reduces Women’s Brain Power

6/22/2009 8:56:52 AM
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PITTSBURGH—Obesity may be linked to a reduced volume of gray matter in the brains of postmenopausal women, according to a new study published in the journal Psychosomatic Medicine: Journal of Biobehavioral Medicine.

“A subset of women from the Pittsburgh Healthy Women Study (HWS) who had been followed for an average of 15 years was invited to participate in brain-imaging studies,” said lead author Isabella Soreca, MD, an assistant professor at the University of Pittsburgh. “We found that those who had gained the most weight had lower gray matter volume. Women who gain weight tend to have high blood pressure, impaired glucose tolerance and other health concerns that are known to affect the brain.”

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Michael 06/22/2009 16:17

As most of us get into middle age, we might take special notice of our body’s ability to keep a few extra pounds around the waist. Most of us understand the importance of eating healthy and the disease risk associated with extra weight around the belly. Recent research suggests the brain’s ability to sense gratification may be critical to overeating behavior. We may have a gene that assists us with knowing when we are filled after eating. Research now indicates that a brain that does not express satiation will lead to continued eating and increased risk of obesity. We know that a healthy diet and regular exercise are very important for maintaining a healthy weight and avoiding obesity. However, genetics also plays a role in which an important neurochemical, Dopamine, may play a critical role. Dopamine is the primary neurochemical that regulates our pleasure sensation. Eating temporarily boosts dopamine levels, but obesity may be associated with fewer Dopamine receptors which lead to less sensation of pleasure with eating. Research now suggests that the brain regions important to Dopamine expression when eating treats such as a milkshake does not get activated in those who are obese. Interestingly, Dopamine has been studied as a primary mechanism for addiction and impulsive behavior including eating. Attempts are underway to try and understand how Dopamine might be triggered even in obesity to reduce impulsive eating so as to reduce gaining more weight.

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